Description
A dual-acting peptide that targets both the GIP and GLP-1 receptors. Frequently studied in glucose regulation and weight-management research due to its influence on insulin response and satiety signaling.
Tirzepatide is a single-molecule peptide built on a GIP-derived 39-residue backbone rather than a simple GLP-1 analogue. Two non-natural Aib residues and a C20 fatty-diacid side chain distinguish it structurally from the GLP-1 analogues in this catalogue.
| Compound | Tirzepatide |
|---|---|
| Also known as | LY3298176 |
| Class | Acylated 39-residue peptide |
| Structure | 39-residue peptide on a GIP-derived backbone, with 2-aminoisobutyric acid (Aib) at positions 2 and 13 and a C-terminal amide. The Lys20 side chain carries a Îł-Glu spacer, two AEEA linker units and an icosanedioic (C20) diacid. |
| Molecular formula | C225H348N48O68 |
| Molecular weight | 4813.5 g/mol (free peptide) |
| CAS number | 2023788-19-2 |
| Appearance | White to off-white lyophilised powder. |
| Purity specification | ≥99% by HPLC |
Every lot ships against its own certificate of analysis. Search by lot number on the certificates of analysis page, or check the paperwork before you order.
Tirzepatide is supplied for laboratory research use only. It is not a drug, food or cosmetic, and it is not for human or veterinary use.
| Reconstitution | Bacteriostatic water or sterile water. |
|---|---|
| Storage, lyophilised | -20 °C, sealed and desiccated, protected from light. |
| Storage, reconstituted | 2-8 °C, protected from light. Use within 2-4 weeks, or freeze single-use aliquots at -20 °C for longer holds. |
| Shipping | Shipped at ambient temperature. Lyophilised material tolerates transit without a cold chain; move it to the freezer on arrival. |
Working notes
- Let a vial come to room temperature before opening it. Opening a cold vial draws in moist air, and lyophilised powder takes up water quickly.
- Add the diluent slowly down the inside wall of the vial rather than directly onto the powder cake, and let it dissolve on its own. Shaking a peptide solution is the fastest way to denature it.
- Wipe the stopper with alcohol before every draw, and keep solutions out of direct light.
- Repeated freeze-thaw cycles cost you more purity than time in the fridge does. If a vial will be used over weeks, aliquot it once and freeze the aliquots.
Additional Information
| Size | 5mg, 10mg, 30mg |
|---|
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