Semaglutide
Price range: $30.00 through $40.00
GLP-1 receptor agonist studied in metabolic and glucose-regulation research.
Description
A GLP-1 receptor agonist engineered with a fatty-acid chain for extended stability. Widely studied in glycemic control and weight-related metabolic research.
Semaglutide is a long-chain acylated analogue of glucagon-like peptide-1, built on the GLP-1(7-37) sequence with two amino-acid substitutions and a fatty-diacid side chain. It is one of the most widely characterised peptides in the current research catalogue, and its structure is fully described in the public chemical literature.
| Compound | Semaglutide |
|---|---|
| Also known as | NN9535, NNC0113-0217, [Aib8,Arg34]GLP-1-(7-37) analogue |
| Class | Acylated 31-residue GLP-1 analogue |
| Structure | 31-residue GLP-1(7-37) backbone with Aib at position 8 and Arg at position 34. The Lys26 side chain carries a Îł-Glu spacer, two AEEA linker units and an octadecanedioic (C18) diacid. Free-acid C-terminus. |
| Molecular formula | C187H291N45O59 |
| Molecular weight | 4113.6 g/mol (free acid) |
| CAS number | 910463-68-2 (free acid) |
| Appearance | White to off-white lyophilised powder. |
| Purity specification | ≥99% by HPLC |
Every lot ships against its own certificate of analysis. Search by lot number on the certificates of analysis page, or check the paperwork before you order.
Semaglutide is supplied for laboratory research use only. It is not a drug, food or cosmetic, and it is not for human or veterinary use.
| Reconstitution | Bacteriostatic water or sterile water. |
|---|---|
| Storage, lyophilised | -20 °C, sealed and desiccated, protected from light. |
| Storage, reconstituted | 2-8 °C, protected from light. Use within 2-4 weeks, or freeze single-use aliquots at -20 °C for longer holds. |
| Shipping | Shipped at ambient temperature. Lyophilised material tolerates transit without a cold chain; move it to the freezer on arrival. |
Working notes
- Let a vial come to room temperature before opening it. Opening a cold vial draws in moist air, and lyophilised powder takes up water quickly.
- Add the diluent slowly down the inside wall of the vial rather than directly onto the powder cake, and let it dissolve on its own. Shaking a peptide solution is the fastest way to denature it.
- Wipe the stopper with alcohol before every draw, and keep solutions out of direct light.
- Repeated freeze-thaw cycles cost you more purity than time in the fridge does. If a vial will be used over weeks, aliquot it once and freeze the aliquots.
Additional Information
| Size | 5mg, 10mg |
|---|
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