Description
A peptide derived from thymosin fraction 5, historically studied for its role in modulating immune cell activity and supporting the body’s regulatory immune response.
Thymosin alpha-1 is a 28-residue peptide with an acetylated N-terminus, originally isolated from thymosin fraction 5. Material labelled "acetate" carries the same CAS number as the parent peptide - the acetate is residual counter-ion from purification, not a separately registered salt.
| Compound | Thymosin alpha-1 (thymalfasin) |
|---|---|
| Also known as | Thymalfasin, T-alpha-1, TA-1 |
| Class | N-acetylated 28-residue peptide |
| Structure | Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH (Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN-OH). N-terminally acetylated, free-acid C-terminus. |
| Molecular formula | C129H215N33O55 |
| Molecular weight | 3108.3 g/mol (free peptide) |
| CAS number | 62304-98-7 |
| Appearance | White to off-white lyophilised powder. |
| Purity specification | ≥99% by HPLC |
Every lot ships against its own certificate of analysis. Search by lot number on the certificates of analysis page, or check the paperwork before you order.
Thymosin Alpha-1 is supplied for laboratory research use only. It is not a drug, food or cosmetic, and it is not for human or veterinary use.
| Reconstitution | Bacteriostatic water or sterile water. |
|---|---|
| Storage, lyophilised | -20 °C, sealed and desiccated, protected from light. |
| Storage, reconstituted | 2-8 °C, protected from light. Use within 2-4 weeks, or freeze single-use aliquots at -20 °C for longer holds. |
| Shipping | Shipped at ambient temperature. Lyophilised material tolerates transit without a cold chain; move it to the freezer on arrival. |
Working notes
- Let a vial come to room temperature before opening it. Opening a cold vial draws in moist air, and lyophilised powder takes up water quickly.
- Add the diluent slowly down the inside wall of the vial rather than directly onto the powder cake, and let it dissolve on its own. Shaking a peptide solution is the fastest way to denature it.
- Wipe the stopper with alcohol before every draw, and keep solutions out of direct light.
- Repeated freeze-thaw cycles cost you more purity than time in the fridge does. If a vial will be used over weeks, aliquot it once and freeze the aliquots.
Additional Information
| Size | 5mg, 10mg |
|---|
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