Description
A cyclic peptide modeled after alpha-melanocyte-stimulating hormone. It nonselectively activates several melanocortin receptors and is studied for its effects on pigmentation pathways and receptor signaling more broadly.
Melanotan II is a cyclic analogue of alpha-MSH(4-13), closed by a side-chain lactam bridge. Its C-terminus is amidated - and that single amide is the only structural difference between Melanotan II and PT-141, which is the free-acid version of the same ring.
| Compound | Melanotan II |
|---|---|
| Also known as | MT-II, MT-2, Melanotan-2 |
| Class | Cyclic 7-residue peptide |
| Structure | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2. N-acetylated, C-terminally amidated, and closed by a lactam bridge between the Asp and Lys side chains. |
| Molecular formula | C50H69N15O9 |
| Molecular weight | 1024.2 g/mol (free base) |
| CAS number | 121062-08-6 (parent compound). Material supplied as the acetate salt weighs more per mole; no distinct acetate CAS is consistently registered, so the parent number is what appears on COAs. |
| Appearance | White to off-white lyophilised powder. |
| Purity specification | ≥98% by HPLC |
Every lot ships against its own certificate of analysis. Search by lot number on the certificates of analysis page, or check the paperwork before you order.
Melanotan II is supplied for laboratory research use only. It is not a drug, food or cosmetic, and it is not for human or veterinary use.
| Reconstitution | Bacteriostatic water or sterile water. Some lots dissolve more readily if a small volume of diluent is added first and the vial is left to stand. |
|---|---|
| Storage, lyophilised | -20 °C, sealed and desiccated, protected from light. |
| Storage, reconstituted | 2-8 °C, protected from light. Use within 2-4 weeks, or freeze single-use aliquots at -20 °C for longer holds. |
| Shipping | Shipped at ambient temperature. Lyophilised material tolerates transit without a cold chain; move it to the freezer on arrival. |
Working notes
- Let a vial come to room temperature before opening it. Opening a cold vial draws in moist air, and lyophilised powder takes up water quickly.
- Add the diluent slowly down the inside wall of the vial rather than directly onto the powder cake, and let it dissolve on its own. Shaking a peptide solution is the fastest way to denature it.
- Wipe the stopper with alcohol before every draw, and keep solutions out of direct light.
- Repeated freeze-thaw cycles cost you more purity than time in the fridge does. If a vial will be used over weeks, aliquot it once and freeze the aliquots.
Additional Information
| Size | 10mg |
|---|
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