Description
A naturally occurring copper-binding tripeptide involved in transporting copper into cells to activate enzymes tied to collagen production and tissue remodeling. Widely researched in skin and wound-healing contexts.
GHK-Cu is a copper(II) complex of the tripeptide glycyl-histidyl-lysine. The copper is an integral part of the molecule, not an additive, which is why the powder is blue and why the copper complex carries a different CAS number from the metal-free peptide.
| Compound | GHK-Cu (copper tripeptide-1) |
|---|---|
| Also known as | Copper tripeptide-1, Cu-GHK, glycyl-L-histidyl-L-lysine copper(II) |
| Class | Copper(II) complex of a 3-residue peptide |
| Structure | Gly-His-Lys, chelated to a copper(II) ion through the terminal amine, the histidine imidazole and backbone donor atoms. |
| Molecular formula | C14H22CuN6O4 (neutral complex; published H-counts vary with the convention used for protons displaced on chelation) |
| Molecular weight | ≈403.9 g/mol for the copper complex; the metal-free GHK tripeptide is 340.4 g/mol (C14H24N6O4) |
| CAS number | 89030-95-5 (copper complex). Note: 49557-75-7 is the metal-free GHK tripeptide, without copper - some suppliers print it on copper-complex product by mistake. |
| Appearance | Blue to deep blue powder. The colour comes from the bound copper and is expected; a colourless powder sold as GHK-Cu is a flag worth raising. |
| Purity specification | ≥98% by HPLC |
Every lot ships against its own certificate of analysis. Search by lot number on the certificates of analysis page, or check the paperwork before you order.
GHK-Cu is supplied for laboratory research use only. It is not a drug, food or cosmetic, and it is not for human or veterinary use.
| Reconstitution | Freely soluble in water, giving a characteristic blue solution. |
|---|---|
| Storage, lyophilised | 2-8 °C or -20 °C, sealed and desiccated, protected from light. Hygroscopic. |
| Storage, reconstituted | 2-8 °C, protected from light. Use within 2-4 weeks, or freeze single-use aliquots at -20 °C for longer holds. |
| Shipping | Shipped at ambient temperature. Lyophilised material tolerates transit without a cold chain; move it to the freezer on arrival. |
Working notes
- Let a vial come to room temperature before opening it. Opening a cold vial draws in moist air, and lyophilised powder takes up water quickly.
- Add the diluent slowly down the inside wall of the vial rather than directly onto the powder cake, and let it dissolve on its own. Shaking a peptide solution is the fastest way to denature it.
- Wipe the stopper with alcohol before every draw, and keep solutions out of direct light.
- Repeated freeze-thaw cycles cost you more purity than time in the fridge does. If a vial will be used over weeks, aliquot it once and freeze the aliquots.
Additional Information
| Size | 50mg, 100mg |
|---|
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