Description
A short peptide encoded by mitochondrial DNA rather than the cell nucleus, making it unique among signaling peptides. It’s studied for its role in activating AMPK, a key regulator of cellular energy metabolism.
MOTS-c is a 16-residue peptide encoded in mitochondrial rather than nuclear DNA. It carries two methionine residues, which are the most oxidation-prone of the standard amino acids - worth knowing when planning how long to keep a reconstituted vial.
| Compound | MOTS-c |
|---|---|
| Also known as | Mitochondrial ORF of the 12S rRNA type-c |
| Class | Synthetic 16-residue peptide |
| Structure | H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH (MRWQEMGYIFYPRKLR). Free-acid C-terminus; contains two methionine residues. |
| Molecular formula | C101H152N28O22S2 |
| Molecular weight | 2174.6 g/mol (free peptide) |
| CAS number | 1627580-64-6 |
| Appearance | White to off-white lyophilised powder. |
| Purity specification | ≥99% by HPLC |
Every lot ships against its own certificate of analysis. Search by lot number on the certificates of analysis page, or check the paperwork before you order.
MOTS-c is supplied for laboratory research use only. It is not a drug, food or cosmetic, and it is not for human or veterinary use.
| Reconstitution | Bacteriostatic water or sterile water; the hydrophobic residues can make it slower to dissolve than shorter peptides. |
|---|---|
| Storage, lyophilised | -20 °C, sealed and desiccated, protected from light. |
| Storage, reconstituted | 2-8 °C, protected from light. The two methionine residues are oxidation-sensitive, so keep holds short - 1-2 weeks - or freeze aliquots at -20 °C. |
| Shipping | Shipped at ambient temperature. Lyophilised material tolerates transit without a cold chain; move it to the freezer on arrival. |
Working notes
- Let a vial come to room temperature before opening it. Opening a cold vial draws in moist air, and lyophilised powder takes up water quickly.
- Add the diluent slowly down the inside wall of the vial rather than directly onto the powder cake, and let it dissolve on its own. Shaking a peptide solution is the fastest way to denature it.
- Wipe the stopper with alcohol before every draw, and keep solutions out of direct light.
- Repeated freeze-thaw cycles cost you more purity than time in the fridge does. If a vial will be used over weeks, aliquot it once and freeze the aliquots.
Additional Information
| Size | 10mg |
|---|
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